abstract：:Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvement of neuroinflammation and white matter abnormalities in psychiatric disorders and neurodegenerative diseases. Cuprizon...

journal_title：Behavioural brain research

authors： Serra-de-Oliveira N,Boilesen SN,Prado de França Carvalho C,LeSueur-Maluf L,Zollner Rde L,Spadari RC,Medalha CC,Monteiro de Castro G

更新日期：2015-01-01 00:00:00

abstract：:Treatment of anxiety disorders by either pharmacological or behavioral means is applied with the intention to directly target the limbic system or high brain centers that down-regulate limbic activity. In spite of intense and long treatment, remission is not achieved in many patients, suggesting that their pathophysio...

journal_title：Behavioural brain research

authors： Shefer S,Gordon C,Avraham KB,Mintz M

更新日期：2015-01-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder with a characteristic triad of cognitive, affective and motor symptoms. Transgenic HD mice show excellent construct and face validity for many of these symptoms, however the decline in some facets of every day activity in humans is difficul...

journal_title：Behavioural brain research

authors： Mo C,Renoir T,Hannan AJ

更新日期：2015-01-01 00:00:00

abstract：:Psychostimulant substances have been found to either increase or inhibit impulsive choice (preference to choose small immediate reward over large delayed reward) in laboratory animals. Although central dopamine transmission has been demonstrated to be involved in impulsivity and drug addiction, little is known regardi...

journal_title：Behavioural brain research

authors： Li Y,Zuo Y,Yu P,Ping X,Cui C

更新日期：2015-01-01 00:00:00

abstract：:Long-term memory of active avoidance in mice is not disturbed by administration of protein synthesis inhibitors (PSIs) when relatively high levels of training are used, whereas a detrimental effect is produced with lower levels of training. PSIs also disrupt extinction of avoidance behaviors in rodents, but it is not ...

journal_title：Behavioural brain research

authors： González-Salinas S,Medina AC,Marín-Vignando V,Ruiz-López CX,Quirarte GL,Prado-Alcalá RA

更新日期：2015-01-01 00:00:00

abstract：:Cognitive deficits are a particularly debilitating symptom group in schizophrenia. We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice. Male and female heterozygous reelin mice (HRM) and wild-type (W...

journal_title：Behavioural brain research

authors： Schroeder A,Buret L,Hill RA,van den Buuse M

更新日期：2015-01-01 00:00:00

abstract：:Across species, greater cortical gyrification, or folding of the cortex, has been shown to be associated with higher cognitive abilities and is thought to reflect an evolutionary process aimed at maximizing the number of cerebral computational units while minimizing the energy and communication costs of larger brains....

journal_title：Behavioural brain research

authors： Gautam P,Anstey KJ,Wen W,Sachdev PS,Cherbuin N

更新日期：2015-01-01 00:00:00

abstract：:Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease ...

journal_title：Behavioural brain research

authors： Savignac HM,Tramullas M,Kiely B,Dinan TG,Cryan JF

更新日期：2015-01-01 00:00:00

abstract：:Neuroimmune signalling underlies addiction and comorbid depression. Clinical observations indicate that infections and chronic lesions are more frequent in drug users and elevated inflammatory states are evident in cocaine dependents. Therefore, lipopolysaccharide (LPS) and inflammatory cytokines represent an importan...

journal_title：Behavioural brain research

authors： Tortorelli LS,Engelke DS,Lunardi P,Mello E Souza T,Santos-Junior JG,Gonçalves CA

更新日期：2015-01-01 00:00:00

abstract：:Pavlovian conditioning of drug effects is generally acknowledged to be a critical factor in the development and persistence of drug addiction. In drug conditioning the focus has essentially been on one type of Pavlovian conditioning, namely, delay conditioning in which the CS and drug UCS overlap and are temporally co...

journal_title：Behavioural brain research

authors： Carey RJ,Carrera MP,Damianopoulos EN

更新日期：2014-12-15 00:00:00

abstract：:Despite the apparent age-related decline in perceptual-motor performance, recent studies suggest that the elderly people can improve their reaction time when relevant sensory information are available. However, little is known about which sensory information may improve motor behaviour itself. Using a synchronization ...

journal_title：Behavioural brain research

authors： Blais M,Martin E,Albaret JM,Tallet J

更新日期：2014-12-15 00:00:00

abstract：:Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar ra...

journal_title：Behavioural brain research

authors： Hao Y,Jing H,Bi Q,Zhang J,Qin L,Yang P

更新日期：2014-12-15 00:00:00

abstract：:It has long been postulated that exogenous cannabinoids have a profound effect on human cognitive functioning. These cannabinoid effects are thought to depend, at least in parts, on alterations of phase-locking of local field potential neuronal firing. The latter can be measured as activity in the theta frequency band...

journal_title：Behavioural brain research

authors： Heitland I,Kenemans JL,Böcker KB,Baas JM

更新日期：2014-11-01 00:00:00

abstract：:The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We investigated the effect of prenata...

journal_title：Behavioural brain research

authors： Abate P,Hernández-Fonseca K,Reyes-Guzmán AC,Barbosa-Luna IG,Méndez M

更新日期：2014-11-01 00:00:00

abstract：:Sociability is the prerequisite to social living. Oxytocin and the hypothalamo-pituitary-adrenocortical axis mediate various social behaviors across different social contexts in different rodents. We hypothesized that they also mediate levels of non-reproductive social behavior. Here we explored naturally occurring va...

journal_title：Behavioural brain research

authors： Qiao X,Yan Y,Tai F,Wu R,Hao P,Fang Q,Zhang S

更新日期：2014-11-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been used as a genetic animal model of attention deficit/hyperactivity disorder (ADHD). SHR/Izm is derived from stroke-resistant SHR as SHR/NIH and SHR/NCrl but from 22nd to 23rd generation descendants of the SHR/NIH ancestor and therefore may show different behavioral phen...

journal_title：Behavioural brain research

authors： Kishikawa Y,Kawahara Y,Yamada M,Kaneko F,Kawahara H,Nishi A

更新日期：2014-11-01 00:00:00

abstract：:Substantial evidence suggests that cerebral deposition of the neurotoxic fibrillar form of amyloid precursor protein, β-amyloid (Aβ), plays a critical role in the pathogenesis of Alzheimer's disease (AD). Yet, many aspects of AD pathology including the cognitive symptoms and selective vulnerability of cortically proje...

journal_title：Behavioural brain research

authors： Parikh V,Bernard CS,Naughton SX,Yegla B

更新日期：2014-11-01 00:00:00

abstract：:Diabetes mellitus, which causes hyperglycemia, affects the central nervous system and can impairs cognitive functions, such as memory. The aim of this study was to investigate the effects of hyperglycemia on memory as well as on the activity of acethylcholinesterase. Hyperglycemia was induced in adult zebrafish by imm...

journal_title：Behavioural brain research

authors： Capiotti KM,De Moraes DA,Menezes FP,Kist LW,Bogo MR,Da Silva RS

更新日期：2014-11-01 00:00:00

abstract：:Within the Pavlovian conditioning framework, extinction is a procedure in which, after conditioning, the conditioned stimulus (CS) is repeatedly presented without the unconditioned stimulus (US). During this procedure the conditioned response (CR) is gradually attenuated. It has been suggested that extinction during t...

journal_title：Behavioural brain research

authors： Revillo DA,Paglini MG,Arias C

更新日期：2014-11-01 00:00:00

abstract：:The behavioral inhibition system (BIS) and the behavioral activation system (BAS) are two fundamental motivational systems which are not only responsible for affective states, behavior and personality, but also related to predispositions for various forms of psychopathology. A wide range of previous studies revealed s...

journal_title：Behavioural brain research

authors： Li Y,Qiao L,Sun J,Wei D,Li W,Qiu J,Zhang Q,Shi H

更新日期：2014-11-01 00:00:00

abstract：:There is evidence that early deprivation of vision prompts the use of body-based, egocentric spatial representations in congenitally blind individuals, whereas previous visual experience favors the use of object-based, allocentric representations (e.g. Pasqualotto A, Spiller MJ, Jansari AS, Proulx MJ. Visual experienc...

journal_title：Behavioural brain research

authors： Iachini T,Ruggiero G,Ruotolo F

更新日期：2014-10-15 00:00:00

abstract：:We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous m...

journal_title：Behavioural brain research

authors： Tabansky I,Quinkert AW,Rahman N,Muller SZ,Lofgren J,Rudling J,Goodman A,Wang Y,Pfaff DW

更新日期：2014-10-15 00:00:00

abstract：:Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and recipr...

journal_title：Behavioural brain research

authors： Hestermann D,Temel Y,Blokland A,Lim LW

更新日期：2014-10-15 00:00:00

abstract：:The present study was aimed to determine how direct injections into the lateral septum (LS) of muscimol and baclofen, GABAA and GABAB receptor agonists, respectively, affect intake of 10% sucrose and sucrose licking activity in rats. The effects of muscimol and baclofen on the 1-h intake of sucrose and sucrose licking...

journal_title：Behavioural brain research

authors： Mitra A,Lenglos C,Timofeeva E

更新日期：2014-10-15 00:00:00

abstract：:Praxis functions are predominantly processed by the left hemisphere. However, limb apraxia is found in less than 50% of patients with left hemisphere damage, and also, although infrequently, in patients with right hemisphere damage. We studied brain representation of preparation/planning of tool-use pantomime separati...

journal_title：Behavioural brain research

authors： Mäki-Marttunen V,Villarreal M,Leiguarda RC

更新日期：2014-10-01 00:00:00

abstract：:Adaptively responding to acute stress has been of great importance for human and animal survival. However, for our species, stress-related disorders are putting an ever-increasing burden on healthcare systems. It is thus crucial to understand the basic processes and cognitive changes associated with acute stress. Here...

journal_title：Behavioural brain research

authors： Passecker J,Barlow S,O'Mara SM

更新日期：2014-10-01 00:00:00

abstract：:Memory consolidation is the process by which recently acquired information becomes stable and is modulated by different neurotransmitters depending on the structure involved and the nature of the memory. Here we evaluate the participation of both D1 and D5 dopamine receptors in the CA1 region of the hippocampus in the...

journal_title：Behavioural brain research

authors： Furini CR,Myskiw JC,Schmidt BE,Marcondes LA,Izquierdo I

更新日期：2014-09-01 00:00:00

abstract：:Trait neuroticism is suggested to be related to measures of volume and function of the hippocampus, a brain structure located in the medial temporal lobe that is critical for human navigation and orientation. In this study, we assessed whether measures of trait neuroticism and self-concept are correlated with the huma...

journal_title：Behavioural brain research

authors： Burles F,Guadagni V,Hoey F,Arnold AE,Levy RM,O'Neill T,Iaria G

更新日期：2014-09-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) acts to promote stress-like physiological and behavioral responses and is mainly expressed in the paraventricular hypothalamic nucleus (PVN). Urocortin 1 (Ucn1) is also a ligand to CRF type 1 and 2 receptors that has been associated with the stress response. Ucn1 neurons are primar...

journal_title：Behavioural brain research

authors： de Andrade JS,Viana MB,Abrão RO,Bittencourt JC,Céspedes IC

更新日期：2014-09-01 00:00:00

abstract：:The cannabinoid system plays a regulatory role in neurotransmission and is involved in the central actions of psychostimulants. This complex interaction between the cannabinoid system and psychostimulants represents a potential pharmacological target for psychosis and addiction. However, most studies have focused on c...

journal_title：Behavioural brain research

authors： Polissidis A,Chouliara O,Galanopoulos A,Naxakis G,Papahatjis D,Papadopoulou-Daifoti Z,Antoniou K

更新日期：2014-08-15 00:00:00

abstract：:A 5-trial inhibitory avoidance test using spontaneously hypertensive rat (SHR) pups has been used as an animal model of attention deficit hyperactivity disorder (ADHD). However, the roles of noradrenergic systems, which are involved in the pathophysiology of ADHD, have not been investigated in this model. In the prese...

journal_title：Behavioural brain research

authors： Kawaura K,Karasawa J,Chaki S,Hikichi H

更新日期：2014-08-15 00:00:00

abstract：:There are several reports that cognitive impairment is observed in stress related disorders and chronic stress impairs learning and memory. However, very few studies have looked into the possible ways of preventing this stress-induced deficit. This research study was conducted to evaluate the effects of quercetin, a n...

journal_title：Behavioural brain research

authors： Mohammadi HS,Goudarzi I,Lashkarbolouki T,Abrari K,Elahdadi Salmani M

更新日期：2014-08-15 00:00:00

abstract：:Development and characterization of animal models of depression are essential for fully understanding the pathogenesis of depression in humans. We made and analyzed a mouse model exhibiting social deficit and hyperphagia-like behavior using a subchronic and mild social defeat stress (sCSDS) paradigm. The body weight, ...

journal_title：Behavioural brain research

authors： Goto T,Kubota Y,Tanaka Y,Iio W,Moriya N,Toyoda A

更新日期：2014-08-15 00:00:00

abstract：:In recent years, the abuse of the club drug gamma-hydroxybutyrate (GHB) has become increasingly popular among adolescents. The drug induces euphoria but can also result in sedation, anaesthesia as well as short-term amnesia. In addition, the abuse of GHB causes cognitive impairments and the mechanism by which GHB indu...

journal_title：Behavioural brain research

authors： Johansson J,Grönbladh A,Hallberg M

更新日期：2014-08-01 00:00:00

abstract：:Neuronal damage in the hippocampal formation which is more sensitive to ischemic stimulation and easily injured will cause severe learning and memory impairment. Therefore, inhibiting hippocampal neuron injuries is the main contributor for learning and memory impairment during cerebral ischemia. Hydrogen sulfide (H2S)...

journal_title：Behavioural brain research

authors： Wen X,Qi D,Sun Y,Huang X,Zhang F,Wu J,Fu Y,Ma K,Du Y,Dong H,Liu Y,Liu H,Song Y

更新日期：2014-08-01 00:00:00

abstract：:Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separati...

journal_title：Behavioural brain research

authors： Hensleigh E,Pritchard LM

更新日期：2014-07-15 00:00:00

abstract：:Alcohol hangover (AH) is a particular state after binge-like drinking. AH begins when ethanol is absent in plasma and is characterized by a cluster of physical and psychological symptoms. Alcohol disrupts circadian patterns of behavioral and physiological parameters; however, the involvement of circadian clock on the ...

journal_title：Behavioural brain research

authors： Karadayian AG,Lores-Arnaiz S,Cutrera RA

更新日期：2014-07-15 00:00:00

abstract：:Reactive oxygen species (ROS) and pro-inflammatory cytokines (PIC) are upregulated in post-traumatic stress disorder (PTSD). Histone deacetylase inhibitors (HDACi) modify genetic transcription and can diminish ROS and PIC escalation. They can also modulate levels of neurotransmitters such as catecholamines and seroton...

journal_title：Behavioural brain research

authors： Wilson CB,McLaughlin LD,Ebenezer PJ,Nair AR,Francis J

更新日期：2014-07-15 00:00:00

abstract：:The large variety of available animal models has revealed much on the neurobiology of depression, but each model appears as specific to a significant extent, and distinction between stress response, pathogenesis of depression and underlying vulnerability is difficult to make. Evidence from epidemiological studies sugg...

journal_title：Behavioural brain research

authors： Harro J,Kanarik M,Kaart T,Matrov D,Kõiv K,Mällo T,Del Río J,Tordera RM,Ramirez MJ

更新日期：2014-07-01 00:00:00

abstract：:Modulation of short-term emotions by long-term mood is little understood but relevant to understand the affective system and of importance in respect to animal welfare: a negative mood might taint experiences, whilst a positive mood might alleviate single negative events. To induce different mood states in sheep housi...

journal_title：Behavioural brain research

authors： Vögeli S,Lutz J,Wolf M,Wechsler B,Gygax L

更新日期：2014-07-01 00:00:00